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Peter De Ceuster | Academic Portfolio
No description available.
ARTICENTER
Theory of Negative Mass
Analysing the structural integrity of photons. by
Integrating Circadian Rhythm and Neurobiology in Precision Medicine: A Novel Approach for Treating Severe Autism Through the Exploration of Time Cells and Genetic Mechanisms
Directed evolution. by
Integrating Circadian Rhythm and Neurobiology in Precision Medicine: A Novel Approach for Treating Severe Autism Through the Exploration of Time Cells and Genetic Mechanisms
The SCN synchronizes peripheral and central clocks via signaling molecules such as vasoactive intestinal peptide (VIP) and arginine vasopressin (AV...
Integrating Circadian Rhythm and Neurobiology in Precision Medicine: A Novel Approach for Treating Severe Autism Through the Exploration of Time Cells and Genetic Mechanisms
At the molecular core, the circadian clock is built upon transcriptional–translational feedback loops (TTFLs). CLOCK and BMAL1 drive expression of
Integrating Circadian Rhythm and Neurobiology in Precision Medicine: A Novel Approach for Treating Severe Autism Through the Exploration of Time Cells and Genetic Mechanisms
Time cells in the hippocampus and medial prefrontal cortex represent sequentially firing neurons that encode temporal structure during cognitive ta...
Integrating Circadian Rhythm and Neurobiology in Precision Medicine: A Novel Approach for Treating Severe Autism Through the Exploration of Time Cells and Genetic Mechanisms
De Rubeis and colleagues have identified convergent genetic risk factors for ASD, including:
Integrating Circadian Rhythm and Neurobiology in Precision Medicine: A Novel Approach for Treating Severe Autism Through the Exploration of Time Cells and Genetic Mechanisms
Precision medicine aims to tailor therapy to individual genetic and physiological contexts. Integrating circadian biology requires:
Integrating Circadian Rhythm and Neurobiology in Precision Medicine: A Novel Approach for Treating Severe Autism Through the Exploration of Time Cells and Genetic Mechanisms
Circadian disruption worsens repetitive grooming behaviors. Restoring circadian alignment with light entrainment improves social exploration.
Emerging Photonic Principles and Negative Effective Mass: Exploring New Physics in the Tradition of Grothendieck.
We provide a deep, exploration of supersymmetry-inspired methodologies in photonics. We concentrate on conceptual frameworks, experiment design, and
Emerging Photonic Principles and Negative Effective Mass: Exploring New Physics in the Tradition of Grothendieck.
Negative effective mass is innovative, and the idea should focus on phenomenology, device design, and experimental signatures rather than algebraic...
Emerging Photonic Principles and Negative Effective Mass: Exploring New Physics in the Tradition of Grothendieck.
Fluid-theoretic analogies provide powerful conceptual tools for understanding collective photonic phenomena.Hydrodynamic descriptions of light and ...
Emerging Photonic Principles and Negative Effective Mass: Exploring New Physics in the Tradition of Grothendieck.
Erwin Schrödinger his dynamics constrained to surfaces into an extended conceptual discussion tailored for experimentalists and theorists who prefe...
Emerging Photonic Principles and Negative Effective Mass: Exploring New Physics in the Tradition of Grothendieck.
We treat the Bollobás–Riordan polynomial as a conceptual tool for classifying topological features of photonic networks without reproducing combina...
Emerging Photonic Principles and Negative Effective Mass: Exploring New Physics in the Tradition of Grothendieck.
Dark photon analogues in photonics provide a fertile testbed for exploring vortex formation, spontaneous symmetry breaking, and emergent coherence ...
Emerging Photonic Principles and Negative Effective Mass: Exploring New Physics in the Tradition of Grothendieck.
We could evelop an extended conceptual narrative of mirror symmetry as it pertains to contemporary photonic research. Rather than presenting formal...
Breaking Ground The Latest Focus of Our Scientific Research
Where science is made! by
Unlocking the Mysteries of Photonics: An In-Depth Look at "The Photon Unraveled"
Introduction to Photonics. Photonics is a branch of science that focuses on the study and application of light (photons). It encompasses the genera...
Play-Based Interventions for Promoting Positive Developmental Outcomes in Autism Spectrum Disorder: A Comprehensive Therapeutic Protocol Informed by Neuroscience, Developmental Psychology, and Positive Psychology.
*An updated version of this work, with the extensive protocol, and additional content covering the subconscious you may find on the CERN server*
Play-Based Interventions for Promoting Positive Developmental Outcomes in Autism Spectrum Disorder: A Comprehensive Therapeutic Protocol Informed by Neuroscience, Developmental Psychology, and Positive Psychology.
Building bridges through play highlights the relational aspects of therapeutic engagement. Play serves as a universal language through which childr...
Play-Based Interventions for Promoting Positive Developmental Outcomes in Autism Spectrum Disorder: A Comprehensive Therapeutic Protocol Informed by Neuroscience, Developmental Psychology, and Positive Psychology.
Intervention design within this framework involves both macro-level planning and micro-level improvisation. At the macro level, interventions are s...
Play-Based Interventions for Promoting Positive Developmental Outcomes in Autism Spectrum Disorder: A Comprehensive Therapeutic Protocol Informed by Neuroscience, Developmental Psychology, and Positive Psychology.
The comprehensive therapeutic protocol outlined here positions play as both a psychological tool and a molecular catalyst for positive development ...
Play-Based Interventions for Promoting Positive Developmental Outcomes in Autism Spectrum Disorder: A Comprehensive Therapeutic Protocol Informed by Neuroscience, Developmental Psychology, and Positive Psychology.
Play has long been recognized as a central mechanism through which children learn, adapt, and thrive. In developmental psychology, play is not mere...
Play-Based Interventions for Promoting Positive Developmental Outcomes in Autism Spectrum Disorder: A Comprehensive Therapeutic Protocol Informed by Neuroscience, Developmental Psychology, and Positive Psychology.
Playful pathways refer to structured therapeutic designs that leverage the progression of play activities to scaffold increasingly complex developm...
Play-Based Interventions for Promoting Positive Developmental Outcomes in Autism Spectrum Disorder: A Comprehensive Therapeutic Protocol Informed by Neuroscience, Developmental Psychology, and Positive Psychology.
While therapeutic play interventions are often designed with a focus on remediating deficits, the potential of play extends into the cultivation of...
Unveiling Temporal Dynamics Probing Serotonin and
Dopamine Effects on Time Cell Function Through Integrated Approaches
Part I: Unveiling Temporal Dynamics. A comprehensive exploration of the neurobiological and molecular underpinnings of time perception.
Unveiling Temporal Dynamics Probing Serotonin and
Dopamine Effects on Time Cell Function Through Integrated Approaches
Part II: Serotonergic Modulation. An in-depth analysis of how 5-HT receptor subtypes regulate temporal processing and patience.
Unveiling Temporal Dynamics Probing Serotonin and
Dopamine Effects on Time Cell Function Through Integrated Approaches
Part III: Dopaminergic Signaling. Dissecting the roles of D1 and D2 receptors in regulating the speed and motivation of the internal clock.
Unveiling Temporal Dynamics Probing Serotonin and
Dopamine Effects on Time Cell Function Through Integrated Approaches
Part IV: Circuit Dynamics. Exploring the interplay between hippocampal time cells, cortical oscillators, and striatal coincidence detectors.
Unveiling Temporal Dynamics Probing Serotonin and
Dopamine Effects on Time Cell Function Through Integrated Approaches
Part V: Computing Time. A rigorous examination of the computational models that describe how the brain encodes duration and variability.
Unveiling Temporal Dynamics Probing Serotonin and
Dopamine Effects on Time Cell Function Through Integrated Approaches
Part VI: Clinical Perspectives. Examining how neurodegenerative and psychiatric disorders reveal the underlying machinery of the internal clock.
Unveiling Temporal Dynamics Probing Serotonin and
Dopamine Effects on Time Cell Function Through Integrated Approaches
Part VII: Synthesis & References. Integrating the molecular, circuit, and computational levels into a unified model, followed by cited literature.
Harnessing Directed Evolution Techniques to Target
GABA Receptors, Transporters, and GABA Transaminase in ASD
Part I: Introduction. Exploring the critical role of GABAergic signaling dysfunction and the Excitation/Inhibition imbalance in Autism Spectrum Dis...
Harnessing Directed Evolution Techniques to Target
GABA Receptors, Transporters, and GABA Transaminase in ASD
Part II: Directed Evolution of Receptors. Engineering the next generation of GABA-A receptors to restore inhibitory tone in ASD.
Harnessing Directed Evolution Techniques to Target
GABA Receptors, Transporters, and GABA Transaminase in ASD
Part III: Engineering Transporters. Modifying GABA transporters (GAT-1 and GAT-3) to finetune synaptic GABA levels.
Harnessing Directed Evolution Techniques to Target
GABA Receptors, Transporters, and GABA Transaminase in ASD
Part IV: GABA-T. Targeting the metabolic breakdown of GABA. From Vigabatrin to next-generation suicide inhibitors.
Harnessing Directed Evolution Techniques to Target
GABA Receptors, Transporters, and GABA Transaminase in ASD
Part V: Viral Delivery. Crossing the blood-brain barrier and targeting specific interneurons with engineered AAV vectors.
Harnessing Directed Evolution Techniques to Target
GABA Receptors, Transporters, and GABA Transaminase in ASD
Part VI: Clinical Perspectives. Moving from the bench to the bedside: stratification of patients and the future of personalized GABAergic therapy.
Harnessing Directed Evolution Techniques to Target
GABA Receptors, Transporters, and GABA Transaminase in ASD
Part VII: Synthesis. Summarizing the potential of directed evolution in GABAergic therapy and citing key references.
Harnessing Single-Cell Omics, CRISPR, MSCs, miRNAs,
and Valproic Acid Targeting SHANK3 Mutations and Associated Pathways
Part I: Introduction. The master scaffolder of the synapse: SHANK3 and its critical role in Autism and Phelan-McDermid Syndrome.
Harnessing Single-Cell Omics, CRISPR, MSCs, miRNAs,
and Valproic Acid Targeting SHANK3 Mutations and Associated Pathways
Part II: Single-Cell Omics. Deciphering the cellular heterogeneity of SHANK3 deficiency using single-cell RNA sequencing and proteomics.
Harnessing Single-Cell Omics, CRISPR, MSCs, miRNAs,
and Valproic Acid Targeting SHANK3 Mutations and Associated Pathways
Part III: CRISPR-Cas9. From modeling to therapy: Using gene editing to restore SHANK3 function in neurons.
Harnessing Single-Cell Omics, CRISPR, MSCs, miRNAs,
and Valproic Acid Targeting SHANK3 Mutations and Associated Pathways
Part IV: MSCs and Exosomes. Harnessing the paracrine power of Mesenchymal Stem Cells and their exosomes to rescue SHANK3 deficits.
Harnessing Single-Cell Omics, CRISPR, MSCs, miRNAs,
and Valproic Acid Targeting SHANK3 Mutations and Associated Pathways
Part V: miRNA Regulation. Unlocking the post-transcriptional control of SHANK3: The role of miR-7, miR-34a, and miR-504.
Harnessing Single-Cell Omics, CRISPR, MSCs, miRNAs,
and Valproic Acid Targeting SHANK3 Mutations and Associated Pathways
Part VI: Valproic Acid. Repurposing an old drug for new tricks: How Valproic Acid modulates SHANK3 expression through epigenetics.
Harnessing Single-Cell Omics, CRISPR, MSCs, miRNAs,
and Valproic Acid Targeting SHANK3 Mutations and Associated Pathways
Part VII: Synthesis and References. Integrating genetic, cellular, and epigenetic strategies for a comprehensive approach to SHANK3-related ASD.
Exploring the Specificity of PHA 543613's Action on α7
nAChR in ASD Therapy
Part I: Introduction. The cholinergic hypothesis of Autism: Why the alpha-7 nicotinic receptor is a prime therapeutic target.
Exploring the Specificity of PHA 543613's Action on α7
nAChR in ASD Therapy
Part II: The Molecule. Mechanism of action and pharmacological profile of PHA 543613 as a potent alpha-7 nAChR agonist.
Exploring the Specificity of PHA 543613's Action on α7
nAChR in ASD Therapy
Part III: Cognitive Rescue. How PHA 543613 restores memory and synaptic plasticity in models of neurocognitive dysfunction.
Exploring the Specificity of PHA 543613's Action on α7
nAChR in ASD Therapy
Part IV: Sensory Gating. PHA 543613
Exploring the Specificity of PHA 543613's Action on α7
nAChR in ASD Therapy
Part V: Neuroprotection. The anti-inflammatory and neuroprotective properties of PHA 543613 in the autistic brain.
Exploring the Specificity of PHA 543613's Action on α7
nAChR in ASD Therapy
Part VI: Comparisons. PHA 543613 versus other alpha-7 nAChR agonists: Why specificity matters for safety and efficacy.
Exploring the Specificity of PHA 543613's Action on α7
nAChR in ASD Therapy
Part VII: Synthesis and References. Integrating findings on PHA 543613 and outlining the path forward for clinical application.
Unraveling Pathways: Exploring the Potential of F.
prausnitzii A2-165 in ASD Drug Discovery
Part I: Introduction. Unraveling the role of the keystone bacterium F. prausnitzii in the autistic gut and its implications for neurodevelopment.
Unraveling Pathways: Exploring the Potential of F.
prausnitzii A2-165 in ASD Drug Discovery
Part II: The Bacterium. A deep dive into the biology of F. prausnitzii, an extremely oxygen-sensitive anaerobe that fuels the gut.
Unraveling Pathways: Exploring the Potential of F.
prausnitzii A2-165 in ASD Drug Discovery
Part III: Butyrate. Unlocking the power of the short-chain fatty acid butyrate: fuel for the gut and an epigenetic regulator for the brain.
Unraveling Pathways: Exploring the Potential of F.
prausnitzii A2-165 in ASD Drug Discovery
Part IV: Gut-Brain Axis. Exploring the biological highways that link the gut to the brain, and how F. prausnitzii regulates traffic.
Unraveling Pathways: Exploring the Potential of F.
prausnitzii A2-165 in ASD Drug Discovery
Part V: Inflammation. How F. prausnitzii modulates the immune system to quell the fire of neuroinflammation in the autistic brain.
Unraveling Pathways: Exploring the Potential of F.
prausnitzii A2-165 in ASD Drug Discovery
Part VI: Therapy. The challenge of delivering an oxygen-sensitive bacterium, and the rise of next-generation probiotics for ASD.
Unraveling Pathways: Exploring the Potential of F.
prausnitzii A2-165 in ASD Drug Discovery
Part VII: Synthesis and References. Consolidating the case for F. prausnitzii as a cornerstone of next-generation autism therapies.
Utilizing mTOR Inhibitors as Synergistic Modulators in
Augmenting Stem Cell Therapy for Autism Spectrum Disorder
Part I: mTOR Signaling. Introduction to the master regulator of cell growth and its critical role in neuronal plasticity and autism.
Utilizing mTOR Inhibitors as Synergistic Modulators in
Augmenting Stem Cell Therapy for Autism Spectrum Disorder
Part II: Hyperactivation. How an overactive mTOR pathway leads to the structural and functional deficits observed in the autistic brain.
Utilizing mTOR Inhibitors as Synergistic Modulators in
Augmenting Stem Cell Therapy for Autism Spectrum Disorder
Part III: Rapalogs. From soil bacteria to brain rescue: tracing the evolution of rapamycin and its analogs drug discovery.
Utilizing mTOR Inhibitors as Synergistic Modulators in
Augmenting Stem Cell Therapy for Autism Spectrum Disorder
Part IV: Stem Cells. How patient-derived stem cells are revolutionizing our understanding of mTOR dysfunction and offering a platform for personali...
Utilizing mTOR Inhibitors as Synergistic Modulators in
Augmenting Stem Cell Therapy for Autism Spectrum Disorder
Part V: Synaptic Rescue. Can we prune the unpruned? Exploring how mTOR inhibition restores synaptic architecture and functional balance.
Utilizing mTOR Inhibitors as Synergistic Modulators in
Augmenting Stem Cell Therapy for Autism Spectrum Disorder
Part VI: Safety Considerations. Navigating the delicate balance between therapeutic benefit and the risks of long-term mTOR inhibition.
Utilizing mTOR Inhibitors as Synergistic Modulators in
Augmenting Stem Cell Therapy for Autism Spectrum Disorder
Part VII: Synthesis & References. A summary of the potential of mTOR inhibitors in ASD therapy, alongside key scientific references.
Targeting Toll-like Receptors in Neurodegeneration:
The Potential of Engineered Decoy Receptors as Therapeutic Innovations
Part I: Neuroinflammation & TLRs. Introduction to the innate immune system
Targeting Toll-like Receptors in Neurodegeneration:
The Potential of Engineered Decoy Receptors as Therapeutic Innovations
Part II: TLR4 and TLR2. deep dive into the specific receptors driving neurodegeneration and their implication in synaptic loss.
Targeting Toll-like Receptors in Neurodegeneration:
The Potential of Engineered Decoy Receptors as Therapeutic Innovations
Part III: The Mechanism of Decoy Receptors. Exploring how engineered soluble receptors can neutralize toxic signals before they reach the cell.
Targeting Toll-like Receptors in Neurodegeneration:
The Potential of Engineered Decoy Receptors as Therapeutic Innovations
Part IV: Engineering Specificity. How scientists are optimizing decoy receptors to be potent and selective therapeutic agents.
Targeting Toll-like Receptors in Neurodegeneration:
The Potential of Engineered Decoy Receptors as Therapeutic Innovations
Part V: The Blood-Brain Barrier Challenge. Overcoming the most significant obstacle in neurological drug delivery.
Targeting Toll-like Receptors in Neurodegeneration:
The Potential of Engineered Decoy Receptors as Therapeutic Innovations
Part VI: Therapeutic Efficacy Profiles. Reviewing the evidence from animal models that proves decoy receptors can reverse disease pathology.
Targeting Toll-like Receptors in Neurodegeneration:
The Potential of Engineered Decoy Receptors as Therapeutic Innovations
Part VII: The Path Forward. Synthesizing the potential of TLR decoy receptors and the future of neuroimmunology.
Sculpting Silence: Targeting DDX3X and DYRK1A in
Nonverbal Autism
Part I: The Biology of Nonverbal Autism. Unraveling the genetic and neural distinctiveness of minimal verbal ability.
Sculpting Silence: Targeting DDX3X and DYRK1A in
Nonverbal Autism
Part II: DDX3X Mutations. Exploring the role of this RNA helicase in brain development and its link to speech deficits.
Sculpting Silence: Targeting DDX3X and DYRK1A in
Nonverbal Autism
Part III: DYRK1A Kinase. Investigating the dose-dependent effects of this gene on neurogenesis and synapse formation.
Sculpting Silence: Targeting DDX3X and DYRK1A in
Nonverbal Autism
Part IV: Neuro-Organoid Disease Models. Using lab-grown mini-brains to study the developmental origins of nonverbal autism.
Sculpting Silence: Targeting DDX3X and DYRK1A in
Nonverbal Autism
Part V: Directed Evolution of Molecular Interventions. Developing next-generation therapies to correct DDX3X and DYRK1A dysfunction.
Sculpting Silence: Targeting DDX3X and DYRK1A in
Nonverbal Autism
Part VI: Circuit-Level Disconnects. Mapping the neural wiring faults that disrupt speech production.
Sculpting Silence: Targeting DDX3X and DYRK1A in
Nonverbal Autism
Part VII: Emerging Therapies & References. A synthesis of the path forward for treating nonverbal autism.
Alona's Sunkissed Escape
Escape the crowds and discover the raw beauty of Ilocos Norte. From golden sand dunes to historic sites, find out why Laoag is the Philippines
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Get the best rates, free breakfast, and exclusive perks when you book directly with Alona
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Experience authentic Ilocano cuisine with a farm-to-table philosophy at Alona
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Tips on how to style Filipiniana and ethnic textiles for everyday wear. Modern looks with Apayao Threads.
Alona's Sunkissed Escape
We ship globally. Shop authentic Filipino fashion from anywhere in the world. Fast and secure delivery from Alona
Alona's Sunkissed Escape
Discover why thousands of expats are calling the Philippines home. From stunning beaches to a lower cost of living, here is why you should make the...
Alona's Sunkissed Escape
State of the internet in the Philippines. Fiber, 5G, and Starlink. Best providers for digital nomads.
Alona's Sunkissed Escape
Step-by-step guide to importing pets to the Philippines. Requirements, permits, and quarantine rules for dogs and cats.
Alona's Sunkissed Escape
Guide to hiring household help in the Philippines. Salaries, benefits, and laws regarding maids (kasambahay) and drivers.
Alona's Sunkissed Escape
Overview of tax obligations for expats in the Philippines. Income tax, VAT, and tax treaties.
Alona's Sunkissed Escape
How to ship goods to the Philippines. The Balikbayan box system, shipping times, and customs rules.
Alona's Sunkissed Escape
A guide to Filipino social etiquette. Understanding hiya, pakikisama, and common social faux pas.
Alona's Sunkissed Escape
Basic Filipino (Tagalog) and Ilocano phrases for expats. How to get by and impress the locals.
Alona's Sunkissed Escape
A guide to dating and relationships in the Philippines for expats. Traditional courtship, family values, and cross-cultural tips.
Alona's Sunkissed Escape
Experience the vibrant festival culture of the Philippines. From Christmas in September to town fiestas.
Alona's Sunkissed Escape
Understanding the role of religion in Filipino society. Catholicism, other denominations, and respecting local beliefs.
Alona's Sunkissed Escape
A detailed breakdown of the cost of living in the Philippines. Rent, food, utilities, and entertainment expenses explained.
Alona's Sunkissed Escape
Where to find other expats in the Philippines. Clubs, organizations, and popular hangouts for foreigners.
Alona's Sunkissed Escape
What to do in your free time in the Philippines. Golf, diving, hiking, and shopping.
Alona's Sunkissed Escape
Where is the best place to retire in the Philippines? Comparing Manila, Cebu, Dumaguete, and Ilocos.
Alona's Sunkissed Escape
Comparing life in Manila vs the province. Infrastructure, cost, and lifestyle trade-offs.
Alona's Sunkissed Escape
Options for elderly care in the Philippines. In-home caregivers vs nursing homes. Why it is a top destination for retirees.
Alona's Sunkissed Escape
Guide to starting a business in the Philippines for foreigners. 60/40 rule, registration process, and opportunities.
Alona's Sunkissed Escape
A guide to investing in Philippine real estate. Buying condos, long-term leasing land, and property appreciation.
Alona's Sunkissed Escape
Why every expat needs an exit plan. Repatriation insurance, emergency funds, and wills in the Philippines.
Alona's Sunkissed Escape
The final checklist before moving to the Philippines. Documents, vaccinations, and packing essentials.
Alona's Sunkissed Escape
Finding the perfect home in the Philippines. Pros and cons of condos, houses, and renting vs buying for foreigners.
Alona's Sunkissed Escape
Discover the flavors of the Philippines. From street food to fine dining, learn what to eat and where to find the best local dishes.
Alona's Sunkissed Escape
Navigating transportation in the Philippines. A guide to Grab, jeepneys, buses, and driving yourself.
Alona's Sunkissed Escape
A guide to the healthcare system in the Philippines for expats. Hospitals, insurance, and medical costs explained.
Alona's Sunkissed Escape
Honest advice on safety and security for expats in the Philippines. Crime rates, safe areas, and common sense tips.
Alona's Sunkissed Escape
Guide to Philippine visas for foreigners. Tourist visa extensions, SRRV retirement visa, Balikbayan privilege, and 13A marriage visa.
Alona's Sunkissed Escape
How to open a bank account in the Philippines as a foreigner. Transferring money, using ATMs, and managing finances.
Alona's Sunkissed Escape
Discover the magic of the Filipino sari-sari store. A cultural icon and the heart of every barangay.
Alona's Sunkissed Escape
Must-try Filipino snacks or
Alona's Sunkissed Escape
Dare to eat? A guide to Filipino street food. Isaw (chicken intestines), Balut (duck embryo), and sweet treats like Banana Cue.
Alona's Sunkissed Escape
Why you should shop at the local public market (palengke). Fresh seafood, tropical fruits, and haggling tips.
Alona's Sunkissed Escape
How to ride a jeepney and tricycle in the Philippines. Payment etiquette, routes, and what to expect.
Alona's Sunkissed Escape
What a typical day looks like in provincial Philippines. Rising early, siestas, and the slow pace of life.
Alona's Sunkissed Escape
The importance of buying local in the Philippines. Supporting farmers, artisans, and family-owned businesses.
Directed Evolution of the BpsA Carrier Protein Domain for Enhanced Activation by Non-Cognate 4'-Phosphopantetheinyl Transferases Implications for ASD Drug Discovery
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by challenges in social interaction, communication, and repe...
Directed Evolution of the BpsA Carrier Protein Domain for Enhanced Activation by Non-Cognate 4'-Phosphopantetheinyl Transferases Implications for ASD Drug Discovery
The BpsA carrier protein domain is integral to the biosynthesis of polyketides, a class of secondary metabolites with diverse biological activities...
Directed Evolution of the BpsA Carrier Protein Domain for Enhanced Activation by Non-Cognate 4'-Phosphopantetheinyl Transferases Implications for ASD Drug Discovery
The carrier protein domain of BpsA adopts a characteristic fold, often consisting of a four-helix bundle or a similar structural motif. This fold p...
Directed Evolution of the BpsA Carrier Protein Domain for Enhanced Activation by Non-Cognate 4'-Phosphopantetheinyl Transferases Implications for ASD Drug Discovery
Directed Evolution Techniques and Their Medical Implications
Directed Evolution of the BpsA Carrier Protein Domain for Enhanced Activation by Non-Cognate 4'-Phosphopantetheinyl Transferases Implications for ASD Drug Discovery
One promising approach involves enhancing serotonin synthesis by upregulating the expression of tryptophan hydroxylase (TPH). By interacting with s...
Directed Evolution of the BpsA Carrier Protein Domain for Enhanced Activation by Non-Cognate 4'-Phosphopantetheinyl Transferases Implications for ASD Drug Discovery
When we enhance brain-derived neurotrophic factor (BDNF) expression by interacting with specific transcription factors or enhancer elements in the ...
Alona's Sunkissed Escape
Explore Ilocos Norte with ease. From scooter rentals to airport transfers, Alona
Alona's Sunkissed Escape
Rent a high-quality scooter at Alona
Alona's Sunkissed Escape
Start your vacation stress-free. Book our private airport transfer from Laoag International Airport directly to Alona
Alona's Sunkissed Escape
Explore Ilocos Norte
Alona's Sunkissed Escape
We prioritize your safety. Learn about the rigorous maintenance standards for our scooters and vehicles at Alona
Alona's Sunkissed Escape
Discover the best road trip routes in Ilocos Norte. From the Coastal Loop to the Heritage Trail, explore like a local.
Alona's Sunkissed Escape
Get rewarded for your adventures. Join Alona
Our Literature
Welcome to Luminous Pages
ARTICENTER › LIVEBOOK
SONNETS FROM HAFEZ
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
ARTICENTER › RECIPES
Recipes
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
BOOK
Luminous Pages — Short Stories
Immerse yourself in original short fiction. From noir mysteries to gothic tales, read our latest stories.
Media Gallery | Luminous Pages
Explore the media gallery of Luminous Pages. Book covers, trailers, and exclusive content from Peter De Ceuster
Luminous Pages — Filipino Prose | Read, Feel, and Own the Story
Discover original Filipino prose with English translations. Read beautiful excerpts, feel the craft, then explore our library and shop to bring the books home.
Media
Welcome to your all-in-one destination in the Philippines! Stay in welcoming accommodations, dine elegantly and locally, explore with tours & rentals, enjoy wellness & culture. Books, software, animations, music, blog, and more.
BOOK › BOOK-A
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
BOOK › BOOK-B
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
BOOK › BOOK-C
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
BOOK › BOOK-D
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
BOOK › BOOK-E
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
BOOK › BOOK-F
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
BOOK › BOOK-HH
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
BOOK › LIBRARY
Alona's Escape Library
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
BOOK › LIBRARY › CUSTOMERS
Luminous Pages - Elegant Book Collection
Discover our curated collection of literary masterpieces, from classic fiction to insightful non-fiction. Explore books on literature, autism care, physics, and thrilling mysteries.
BOOK › PREVIEW
Book Preview
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
BOOK › SCROLLER
New Horizons in Autism Care
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness.
Literature Gallery
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Literature Gallery
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness.
Literature Gallery
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
City of Quiet Knots
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness.
City of Quiet Knots
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Conference of the Birds
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness.
Conference of the birds
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Unleash Your Power
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness.
Unleash Your Power
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
CODE
Update Available - Fintech Synergy
No description available.
Python 01 — Setup and Your First Script | SigLabs Code
Install Python, choose a great editor, run your first script, and learn the REPL. Clear steps and best practices.
Python 05 — OOP, async, and HTTP | SigLabs Code
Build with classes and dataclasses, use async/await for concurrency, and call APIs with requests.
Python 04 — Files, Errors, and Testing | SigLabs Code
Read and write files safely, handle exceptions, and write lean tests with pytest.
Python 03 — Functions, Modules, and venv | SigLabs Code
Write clear functions, structure code with modules, and isolate dependencies with virtual environments (venv).
Python 02 — Data Types and Control Flow | SigLabs Code
Numbers, strings, collections, conditionals, loops, and comprehensions with clear examples and best practices.
SigLabs Code — Python Tutorials & Financial Software
Master Python with concise, high‑quality lessons and discover SigLabs financial software for traders, analysts, and teams.
CODE › CUSTOMER
FinTech Synergy | Professional Trading & Forecasting Suite
The ultimate financial software suite. AI-driven forecasting, professional charting, and automated trading execution in one platform.
Download Software — FinTech Synergy
Download the latest version of the FinTech Synergy Suite. License required for installation.
Contact & Request Demo — FinTech Synergy
Request a personalized demo or contact sales for FinTech Synergy Suite. Tell us your use case and we
DATABANK
SIG Databank | Research Repository
Access the complete SIG Labs research repository. Whitepapers, studies, and technical documentation.
DOC
Terms of Service | SIG Labs
Terms of Service for SIG Labs covering hospitality, restaurant, events, and retail/trader services.
Privacy Policy | SIG Labs
Privacy Policy describing how SIG Labs collects, uses, and protects personal information across hospitality, restaurant, events, and retail services.
Media & Brand Asset License | SIG Labs
License terms for media, brand assets, and downloads from SIG Labs websites and services, including permitted and prohibited uses.
Content & Software License | SIG Labs
Content and Software License for SIG Labs websites and services, including permitted uses and restrictions.
Software Distribution Notice | SIG Labs
Professional software distribution notice covering commercial and open-source components used by SIG Labs.
PEN
Press coverage
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Correspondence
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Scientific Medias
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Scientific Journals
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Scientific Publications
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Excerpt
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Our Articles
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Affiliation
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
PEN › GATE
Publications intro
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
PEN › GATE › DOCU
A Gaze Within | SIG Labs
SIG Labs Cinematic Experience
A Speck of Light | SIG Labs
SIG Labs Cinematic Experience
PHOTO
Sig Labs Photo Album and Blog
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Sig Labs Photo Album and Blog
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Sig Labs Photo Album and Blog
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
Sig Labs Photo Blog
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
About
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
PHOTO › EXPANSION
Sig Labs Photo Album and Blog
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
PHOTO › EXTENSION
Family Chronicles
More than just a staycation. Enjoy rooms, tours, and dining alongside scooter rentals and wellness. Visit our on-site clothing, book, and software stores today.
RESTAURANT
Yoga & Wellness Sanctuary - Alona's Sunkissed Escape®
Professional Wellness Sanctuary at Alona
Yoga & Wellness Sanctuary | Alona's Escape
Professional beach yoga, massage therapy, and advanced skincare in Caaoacan Beach Front. Reconnect with your inner peace.
Thank You • Payment Received
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Thank You • Payment Received (Tours)
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Thank You • Payment Received (Scooters)
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Selling the Story of Heritage Cooking
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Selling the Story of Heritage Cooking
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Alona's Sunkissed Escape® | Our Story & Caaoacan Beach Front's Heritage, Laoag
Experience Caaoacan Beach Front, Laoag
Selling the Story of Heritage Cooking
No description available.
Eco Garden Adventures
Experience an eco-friendly Garden in the Philippines with activities for kids and adults. Explore nature, sustainable practices, and family fun!
House Rentals - Alona's Sunkissed Escape®
Stay in our charming homes across the Philippines. Beachfront villas, city apartments, and eco-lodges available for rent.
Alona's Sunkissed Escape® | Beachfront Eco-Resort in Laoag
Experience authentic beachfront luxury at Alona
Privacy Policy | Alona's Leisure Group
Our commitment to your privacy. Learn how Alona
Payment Cancelled
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Payment Cancelled (Tours)
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Payment Cancelled (Scooters)
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Partnerships - Alona's Sunkissed Escape®
Explore partnership opportunities with Alona
Savor Tradition: Alona's Highland Flavors
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Eco Tours • Stays • Dining | Alona's Escape, Caaoacan
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Scooter Rentals - Alona's Escape
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Scooter Rentals | Alona's Escape
Rent a scooter in Caaoacan Beach Front and Apayao. Reliable bikes, fair prices, and local route tips. Book online today.
Guesthouse Booking - Alona's Sunkissed Escape®
Book your stay at Alona
Book Your Stay | Alona's Sunkissed Escape®
Book your eco-friendly stay at Alona
Alona's | Store Inventory
No description available.
Alona's Sunkissed Escape® – Beachfront Stays, Dining, and Eco‑Tours in Laoag, Ilocos Norte
Beachfront homestay, farm‑to‑table dining, eco‑tours, and scooter rentals at Caaoacan Beach Front, Laoag, Ilocos Norte. Book direct for the best rate. Kids stay free + free breakfast.
Alona's Escape · Sari‑Sari + Mini Grocery
Your friendly neighborhood grocery at Alona
Island Runner – Alona's Sunkissed Escape
Run along our tropical shoreline, collect shells, and dodge driftwood. One-tap controls, family-friendly, and fast on any device.
Digital Knowledge Vault | Unleash Your Power
No description available.
Software Distribution Notice — Alona's Leisure Group
Software Distribution Notice for Alona
Contact & Reservations – Alona's Sunkissed Escape®
Contact Alona
Dining & Reservations | Alona's Highland Flavors
Reserve your table at Alona
RESTAURANT › BLOG
Alonas Leisure Group Partners with Amazon for Global Fulfillment
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Wise - Alona's Sunkissed Escape®
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Blog Post Title - Alona's Sunkissed Escape®
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Alona's Sunkissed Escape® Blog - Stories & Insights
Explore articles on sustainable tourism, heritage cuisine, local adventures, and wellness tips from Alona
Alona's Sunkissed Escape® Blog - Stories & Insights
Explore articles on sustainable tourism, heritage cuisine, local adventures, and wellness tips from Alona
RESTAURANT › HANDCRAFTED
Thanks — Apayao Threads
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Apayao Threads Store – Authentic Filipino Handwoven Clothing & Home Goods
Shop Apayao Threads: ethically made Filipino handwoven dresses, apparel, and home goods. Designed by Alona, woven by indigenous artisans in Apayao & Ilocos. International ordering available.
Apayao Threads | Authentic Handwoven Heritage
Shop ethically made Filipino handwoven dresses and home goods. Designed by Alona, woven by indigenous artisans. Supports Bukas Palad NGO.
Payment Cancelled – Apayao Threads
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RESTAURANT › ITSYSTEM
Tour Packages | Apayao Eco-Tours
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Apayao Eco-Tours | Explore the Hidden Gems of Apayao
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Explore Apayao | Eco-Tours & Adventures
Interactive map and tour booking for Apayao
Contact Us | Apayao Eco-Tours
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Attractions | Apayao Eco-Tours
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About Us | Apayao Eco-Tours
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